Uruguay condemned Uzbekistan to a fifth consecutive defeat by cruising to a comfortable 3-0 victory at the Centenario Stadium in Montevideo on Thursday.
The win means La Celeste head to the World Cup undefeated in eight of their last nine outings.
Giorgian De Arrascaeta sparked wild celebration among the home crowd as he put the ball at the back of the net after Luis Suarez flicked it to him.
The Barcelona number nine got his name on the score-sheet after successfully converting a 54th minute penalty before Jose Maria Gimenez headed in the third goal for Uruguay.
Uzbekistan ended the match with 10 men as Akramjon Komilov was sent off for a high boot challenge on Carlos Sanchez at the 79th minute.